Simultaneous elevation of the serum concentrations of vascular endothelial growth factor and interleukin‐6 as independent predictors of prognosis in aggressive non‐Hodgkin's lymphoma
- 1 February 2002
- journal article
- Published by Wiley in European Journal of Haematology
- Vol. 68 (2), 91-100
- https://doi.org/10.1034/j.1600-0609.2002.01609.x
Abstract
Therapeutic approaches for non-Hodgkin's lymphoma (NHL) are currently based on the International Prognostic Index (IPI). Research on biological prognostic factors has been actively pursued in recent years, with serum vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) being identified as prognostic factors for NHL. Here, we determined that serum VEGF and IL-6 levels are independent prognostic factors for aggressive lymphoma. Compared with normal controls, serum VEGF and IL-6 levels were significantly higher in patients with aggressive lymphoma or adult T-cell leukemia/lymphoma. Furthermore, overall and disease-free survival rates for patients with high levels of VEGF or IL-6 were significantly poorer than for patients with low levels. In addition, the prognosis for patients with high levels of both serum VEGF and IL-6 was significantly poorer than that for patients with high levels of either VEGF or IL-6 or with low levels of both VEGF and IL-6. Multivariate analyses of a variety of prognostic factors, including the five IPI factors, revealed that serum VEGF and IL-6 were both independent prognostic factors for overall survival of aggressive lymphoma. Therefore, a combination of VEGF and IL-6 represents a useful prognostic factor for aggressive lymphoma.Keywords
This publication has 30 references indexed in Scilit:
- Biweekly COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin and procarbazine) regimen combined with granulocyte colony-stimulating factor (G-CSF) for intermediate-grade non-Hodgkin's lymphomaEuropean Journal of Haematology, 2009
- Presalvage prostate‐specific antigen (PSA) and PSA doubling time as predictors of biochemical failure of salvage cryotherapy in patients with locally recurrent prostate cancer after radiotherapyCancer, 2006
- Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingNature, 2000
- Prognostic evaluation in multiple myeloma: an analysis of the impact of new prognostic factorsBritish Journal of Haematology, 1999
- Vascular endothelial growth factor serum concentrations in ovarian cancerObstetrics & Gynecology, 1998
- Angiogenesis spectrum in the stroma of B‐cell non‐Hodgkin's lymphomas. An immunohistochemical and ultrastructural studyEuropean Journal of Haematology, 1996
- The implications of angiogenesis for the biology and therapy of cancer metastasisCell, 1994
- Bone marrow angiogenesis and progression in multiple myelomaBritish Journal of Haematology, 1994
- Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels.The Journal of Experimental Medicine, 1991
- Individual Comparisons by Ranking MethodsJournal of Economic Entomology, 1945