High-Resolution NMR Spectroscopy of a GPCR in Aligned Bicelles
- 18 May 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (23), 7402-7403
- https://doi.org/10.1021/ja0606632
Abstract
Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug−receptor interactions.Keywords
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