Clinical significance of Ki-67 proliferation index in disease progression and prognosis of patients with resected colorectal carcinoma
- 1 June 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 92 (8), 1002-1007
- https://doi.org/10.1002/bjs.4858
Abstract
Background: The prognostic role of proliferation markers in patients with colorectal neoplasia is inconclusive. The aim of this study was to evaluate proliferation markers in patients with colorectal carcinoma, to relate these to standard clinicopathological findings and to investigate their potential role in the prediction of long-term survival. Methods: Archived formalin-fixed, paraffin-embedded tissue samples from a cohort of 106 patients who underwent curative resection for colorectal carcinoma were analysed to determine a Ki-67 (MIB-1)-derived proliferation index (PI) using a double immunostaining technique. The relationship between PI and standard clinicopathological variables was assessed and its association with long-term survival evaluated. Results: A significant association was found between PI and tumour (T) status (P = 0·001), lymph node (N) involvement (P = 0·0098), the presence of distant metastases (P < 0·010) and advanced stage of disease (P < 0·001). On multivariate analysis, PI was shown to be an independent prognostic factor for long-term survival (hazard ratio 2·1 (95 per cent confidence interval 1·1 to 4·1); P = 0·032). Conclusion: Cell proliferation is significantly associated with tumour progression and may be used to identify patients with a predicted adverse outcome after resection of colorectal carcinoma.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology of Japan
This publication has 21 references indexed in Scilit:
- Ki67 protein: the immaculate deception?Histopathology, 2002
- High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomasCancer, 2001
- Prognostic Factors in Colorectal CancerArchives Of Pathology & Laboratory Medicine, 2000
- Tumour markers of prognosis in colorectal cancerBritish Journal of Cancer, 1998
- Proliferation markers in tumours: interpretation and clinical valueJournal of Clinical Pathology, 1998
- MIB-1 labelling index is an independent prognostic marker in primary breast cancerBritish Journal of Cancer, 1998
- Ki67 LABELLING INDEX IN GASTRIC CARCINOMAS. AN IMMUNOHISTOCHEMICAL STUDY USING DOUBLE STAINING FOR THE EVALUATION OF THE PROLIFERATIVE ACTIVITY OF DIFFUSE-TYPE CARCINOMASThe Journal of Pathology, 1997
- Hypodiploidy, Ki-67 growth fraction and prognosis of surgically resected lung cancersBritish Journal of Cancer, 1996
- Immunohistochemical study on the prognostic value of MIB-1 in gastric carcinomaBritish Journal of Cancer, 1996
- The prognostic value of Ki67 immunostaining in non‐Hodgkin's lymphomaThe Journal of Pathology, 1988