Histometric Analysis of Skin-Radiofrequency Interaction Using a Fractionated Microneedle Delivery System
- 1 February 2014
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Dermatologic Surgery
- Vol. 40 (2), 134-141
- https://doi.org/10.1111/dsu.12411
Abstract
Fractionated microneedle radiofrequency (RF) devices have been reported to be effective in treatment of various dermatologic disorders. To analyze histometric changes in skin-RF interactions using a fractionated microneedle delivery system. RF energies were delivered using a fractionated microneedle device to an in vivo minipig model with penetration depths of 0.5, 1.0, 1.5, 2.0, 2.5, and 3.5 mm; RF conduction times of 20, 50, 100, and 1,000 ms; and energy levels of 5.0, 10.0, 20.0, 25.0, 37.5, and 50.0 V. Immediately after treatment, skin samples showed that the RF-induced coagulated columns in the dermis formed a cocoon-shaped zone of sublative thermal injury. Four days after the treatment, skin specimens demonstrated reepithelialization, and the dermal RF-induced coagulated columns showed mixed cellular infiltration, neovascularization, and granulation tissue formation. Microneedle depth and RF conduction times, but not energy level, significantly affected histometric values of RF-induced dermal coagulation. Microneedle RF treatment affected adnexal structures by coagulating follicular epithelium and perifollicular structures. Our data may be of use as an essential reference for choosing RF parameters in treatment of various skin conditions.Keywords
This publication has 9 references indexed in Scilit:
- Evaluation of the Clinical Efficacy of Fractional Radiofrequency Microneedle Treatment in Acne Scars and Large Facial PoresDermatologic Surgery, 2012
- Safety and efficacy of fractional bipolar radiofrequency treatment in Fitzpatrick skin types V–VIJournal of Cosmetic and Laser Therapy, 2012
- Use of Fractionated Microneedle Radiofrequency for the Treatment of Inflammatory Acne Vulgaris in 18 Korean PatientsDermatologic Surgery, 2012
- Evaluation of the Effect of Fractional Laser with Radiofrequency and Fractionated Radiofrequency on the Improvement of Acne ScarsDermatologic Surgery, 2011
- Histological findings in adipocytes when cellulite is treated with a variable-emission radiofrequency systemLasers in Medical Science, 2009
- Pilot clinical study of a novel minimally invasive bipolar microneedle radiofrequency deviceLasers in Surgery and Medicine, 2009
- Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagenesisLasers in Surgery and Medicine, 2009
- The treatment of burn scar–induced contracture with the pinhole method and collagen induction therapy: a case reportJournal of the European Academy of Dermatology and Venereology, 2007
- ImageJ for microscopyBioTechniques, 2007