Pseudo-spin symmetry in nuclei is investigated considering the Dirac equation with a Lorentz structured Woods-Saxon potential. The isospin correlation of the energy splittings of pseudo-spin partners with the nuclear potential parameters is studied. We show that in an isotopic chain, the pseudo-spin symmetry is better realized for neutrons than for protons. This behavior comes from balance effects amongst the central nuclear potential parameters. In general, we found an isospin asymmetry of the nuclear pseudo-spin interaction, opposed to the nuclear spin-orbit interaction which is quasi isospin symmetric.