Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
Top Cited Papers
- 3 November 2016
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 375 (18), 1767-1778
- https://doi.org/10.1056/nejmra1514296
Abstract
The PD-1 pathway plays an essential role in maintaining immunologic self-tolerance. However, cancers can subvert the role of this pathway and blind the immune system to their presence. The molecular details of the pathway are discussed.Keywords
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