Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease
Open Access
- 1 January 2007
- journal article
- research article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2007, 1-5
- https://doi.org/10.1155/2007/45794
Abstract
Objective. To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis.Subject and methods. Eighteen subjects were divided in two groups: experimental (age) and control (age). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Studenttest and.Results. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group ().Conclusion. The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.
Keywords
Funding Information
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
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