COVID-19 in a designated infectious diseases hospital outside Hubei Province, China
Top Cited Papers
Open Access
- 30 June 2020
- Vol. 75 (7), 1742-1752
- https://doi.org/10.1111/all.14309
Abstract
Background The clinical characteristics of novel coronavirus disease (COVID-2019) patients outside the epicenter of Hubei Province are less understood. Methods We analyzed the epidemiological and clinical features of all COVID-2019 cases in the only referral hospital in Shenzhen City, China, from January 11, 2020, to February 6, 2020, and followed until March 6, 2020. Results Among the 298 confirmed cases, 233 (81.5%) had been to Hubei, while 42 (14%) did not have a clear travel history. Only 218 (73.15%) cases had a fever as the initial symptom. Compared with the nonsevere cases, severe cases were associated with older age, those with underlying diseases, and higher levels of C-reactive protein, interleukin-6, and erythrocyte sedimentation rate. Slower clearance of the virus was associated with a higher risk of progression to critical condition. As of March 6, 2020, 268 (89.9%) patients were discharged and the overall case fatality ratio was 1.0%. Conclusions In a designated hospital outside Hubei Province, COVID-2019 patients could be effectively managed by properly using the existing hospital system. Mortality may be lowered when cases are relatively mild, and there are sufficient medical resources to care and treat the disease.Funding Information
- Bill and Melinda Gates Foundation
- Sanming Project of Medicine in Shenzhen (SZSM201612014)
This publication has 16 references indexed in Scilit:
- A Novel Coronavirus from Patients with Pneumonia in China, 2019The New England Journal of Medicine, 2020
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaThe Lancet, 2020
- Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictionsPublished by Cold Spring Harbor Laboratory ,2020
- Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of AmericaAmerican Journal of Respiratory and Critical Care Medicine, 2019
- EASL Clinical Practice Guidelines: Drug-induced liver injuryJournal of Hepatology, 2019
- Fourth Universal Definition of Myocardial Infarction (2018)Journal of the American College of Cardiology, 2018
- Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and hostCurrent Opinion in Virology, 2017
- Middle East respiratory syndromeThe Lancet, 2015
- Clinical Description of a Completed Outbreak of SARS in Vietnam, February–May, 2003Emerging Infectious Diseases, 2004
- Combining Clinical and Epidemiologic Features for Early Recognition of SARSEmerging Infectious Diseases, 2004