The role of nesprins as multifunctional organizers in the nucleus and the cytoskeleton
- 21 November 2011
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 39 (6), 1725-1728
- https://doi.org/10.1042/bst20110668
Abstract
Nesprins (nuclear envelope spectrin repeat proteins), also known as SYNE (synaptic nuclear envelope protein), MYNE (myocyte nuclear envelope protein), ENAPTIN and NUANCE, are proteins that are primarily components of the nuclear envelope. The nuclear envelope is a continuous membrane system composed of two lipid bilayers: an inner and an outer nuclear membrane. Nesprins are components of both nuclear membranes and reach into the nucleoplasm and the cytoplasm, where they undergo different interactions and have the potential to influence transcriptional processes and cytoskeletal activities.This publication has 27 references indexed in Scilit:
- Nesprin-2 Interacts with α-Catenin and Regulates Wnt Signaling at the Nuclear EnvelopeOnline Journal of Public Health Informatics, 2010
- Stabilization of the Spectrin-Like Domains of Nesprin-1α by the Evolutionarily Conserved “Adaptive” DomainCellular and Molecular Bioengineering, 2010
- Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarizationProceedings of the National Academy of Sciences of the United States of America, 2009
- Sun1 forms immobile macromolecular assemblies at the nuclear envelopeBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008
- Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffnessExperimental Cell Research, 2008
- Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatinGenes & Development, 2008
- Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cellsHuman Molecular Genetics, 2007
- The inner nuclear membrane protein Emerin regulates β-catenin activity by restricting its accumulation in the nucleusThe EMBO Journal, 2006
- Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature agingProceedings of the National Academy of Sciences of the United States of America, 2006
- A novel fission yeast gene, kms1 +, is required for the formation of meiotic prophase-specific nuclear architectureMolecular Genetics and Genomics, 1997