Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
Top Cited Papers
Open Access
- 15 November 2011
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Medicine
- Vol. 2 (1), a006346
- https://doi.org/10.1101/cshperspect.a006346
Abstract
Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory pathways, and long-term use of anti-inflammatory drugs is linked with reduced risk to develop the disease. As cause and effect relationships between inflammation and AD are being worked out, there is a realization that some components of this complex molecular and cellular machinery are most likely promoting pathological processes leading to AD, whereas other components serve to do the opposite. The challenge will be to find ways of fine tuning inflammation to delay, prevent, or treat AD.Keywords
This publication has 100 references indexed in Scilit:
- Microglia in human immunodeficiency virus‐associated neurodegenerationGlia, 2002
- Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's diseaseThe FASEB Journal, 2002
- Innate Immune RecognitionAnnual Review of Immunology, 2002
- Intrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic miceNeurobiology of Aging, 2001
- Cyclo-Oxygenase-2 InhibitorsDrugs & Aging, 2000
- THE ROLE OF COMPLEMENT AND COMPLEMENT RECEPTORS IN INDUCTION AND REGULATION OF IMMUNITYAnnual Review of Immunology, 1998
- Response of Glial Cells to Ischemia: Roles of Reactive Oxygen Species and GlutathioneNeuroscience & Biobehavioral Reviews, 1997
- Complement receptors and regulatory proteins: immune adherence revisited and abuse by microorganismsClinical and Experimental Immunology, 1994
- Alzheimer's Disease and Rheumatoid ArthritisRheumatology, 1994
- Complement activation in amyloid plaques in Alzheimer’s dementiaVirchows Archiv B Cell Pathology Including Molecular Pathology, 1988