SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
Open Access
- 19 January 2021
- preprint content
- research article
- Published by Cold Spring Harbor Laboratory in bioRxiv : the preprint server for biology
Abstract
SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and may foreshadow reduced efficacy of current spike-based vaccines.Keywords
This publication has 33 references indexed in Scilit:
- Structural basis of a shared antibody response to SARS-CoV-2Science, 2020
- A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2Science, 2020
- Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of AntibodiesCell, 2020
- Monoclonal Antibodies for Prevention and Treatment of COVID-19JAMA, 2020
- Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 VirusCell, 2020
- Structural Basis for RNA Replication by the SARS-CoV-2 PolymeraseCell, 2020
- Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2Cell, 2020
- A pneumonia outbreak associated with a new coronavirus of probable bat originNature, 2020
- Nextstrain: real-time tracking of pathogen evolutionBioinformatics, 2018
- The Protein Data BankNucleic Acids Research, 2000