What's in a name? eNOS and anaphylactic shock
Open Access
- 1 August 2006
- journal article
- editorial
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 116 (8), 2075-2078
- https://doi.org/10.1172/JCI29406
Abstract
In this issue of the JCI, a study by Cauwels and colleagues suggests a central role for eNOS, the endothelial isoform of nitric oxide synthase, as a mediator of anaphylaxis (see the related article beginning on page 2244). Why is an enzyme originally described as a physiological mediator of vascular homeostasis implicated in the spectacular vascular collapse that is characteristic of anaphylaxis? And is the eNOS involved in anaphylaxis necessarily exerting its effect solely in the vascular endothelium, or might this “endothelial enzyme” actually be playing a more fundamental role in an entirely different tissue? After all, what’s in a name?Keywords
This publication has 20 references indexed in Scilit:
- Anaphylactic shock depends on PI3K and eNOS-derived NOJCI Insight, 2006
- Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene productionBlood, 2004
- Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive FactorCell, 2003
- Anaphylaxis: A review of causes and mechanismsJournal of Allergy and Clinical Immunology, 2002
- Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.JCI Insight, 1997
- Nitric oxide in skeletal muscleNature, 1994
- Invited opinion: role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury.1994
- Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide.Circulation Research, 1993
- Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.Proceedings of the National Academy of Sciences of the United States of America, 1992
- Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.Proceedings of the National Academy of Sciences of the United States of America, 1991