The safety of β‐carotene
- 1 January 1988
- journal article
- review article
- Published by Informa UK Limited in Nutrition and Cancer
- Vol. 11 (4), 207-214
- https://doi.org/10.1080/01635588809513989
Abstract
Epidemiological studies have associated low dietary and/or plasma level of carotenoids with higher incidences of certain cancers. This evidence has led the National Cancer Institute to initiate more than a dozen prospective clinical trials in which supplements of beta-carotene alone, or in combination with other micronutrients, are being taken. In these trials, the beta-carotene supplements are given in the range of 15-50 mg/day. The safety of this level of intake is well documented. beta-Carotene has been successfully used to treat inherited photosensitivity diseases for more than 15 years at dosages of 180 mg/day or more, without any adverse effects other than hypercarotenemia. Toxicity studies in animals have shown that beta-carotene is not carcinogenic, mutagenic, embryotoxic, or teratogenic and does not cause hypervitaminosis A. In the few isolated reports of carotenoid-related toxicity, the findings are associated with very large intakes of foods containing beta-carotene, among other constituents, and have not been substantiated in individuals who have taken high doses of beta-carotene for several years.Keywords
This publication has 35 references indexed in Scilit:
- Serum Beta-Carotene, Vitamins a and E, Selenium, and the Risk of Lung CancerNew England Journal of Medicine, 1986
- Influence of breast-feeding on the restoration of the low serum concentration of vitamin E and β-carotene in the newborn infantAmerican Journal of Obstetrics and Gynecology, 1986
- HypercarotenaemiaBMJ, 1985
- β-Carotene: an Unusual Type of Lipid AntioxidantScience, 1984
- MammalsPublished by Springer Science and Business Media LLC ,1984
- METABOLISM AND NUTRITIONAL SIGNIFICANCE OF CAROTENOIDSAnnual Review of Nutrition, 1981
- Can dietary beta-carotene materially reduce human cancer rates?Nature, 1981
- CAROTENOIDS IN MEDICAL APPLICATIONSPublished by Elsevier BV ,1981
- Dietary vitamin a and human lung cancerInternational Journal of Cancer, 1975
- QUENCHING OF SINGLET OXYGEN*Annals of the New York Academy of Sciences, 1970