Isolation and Structure of Hemibastadinols 1−3 from the Papua New Guinea Marine Sponge Ianthella basta
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 59 (10), 927-934
- https://doi.org/10.1021/np960249n
Abstract
Further investigation of the Bismarck Archipelago (Papua New Guinea) marine sponge Ianthella basta for biologically active constituents has led to the isolation of hemibastadins 1 (2), 2 (3), and 3 (4) and the new brominated tyrosine derivatives hemibastadinols 1−3 (9, 13, and 14). Isolation and structure elucidation of the monomethyl ether derivatives (7 and 8) of hemibastadins 1 and 2 and the 3-bromotyramine amide of oxalic acid amide (1a) concluded our chemical investigation of I. basta. The hemibastadins and hemibastadinols represent important biosynthetic links to a series of bromotyrosine tetramers collectively known as the bastadins. The antimicrobial activity of the bastadins, hemibastadins, and hemibastadinols is summarized.Keywords
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