Evaluation of two glucose meters and interference corrections for screening neonatal hypoglycemia
- 11 February 2015
- journal article
- Published by Wiley in Pediatrics International
- Vol. 57 (4), 603-607
- https://doi.org/10.1111/ped.12543
Abstract
Many neonatal intensive care and maternal units still use self-monitoring of blood glucose (SMBG) devices as a tool to aid diagnosis despite the introduction of point-of-care testing (POCT) devices, which are known to have higher accuracy. We evaluated the performance of two glucose meters, the StatStrip (Nova Biomedical), a POCT device, and the Medisafe Mini (Terumo), an SMBG device, to detect hypoglycemia in neonates. In addition, we evaluated the interference of hematocrit, acetaminophen and ascorbic acid. Whole blood samples were drawn from neonates who were at risk of hypoglycemia and analyzed with the StatStrip and Medisafe Mini. The results were further confirmed with blood gas analyzers ABL825 and BM6050. To evaluate the interference of hematocrit, acetaminophen and ascorbic acid, concentrated solutions of glucose and interfering substances were gravimetrically prepared and analyzed. Among the 222 blood samples analyzed, results from the StatStrip were more closely aligned to those of the ABL825 at all levels of glucose than the Medisafe Mini. StatStrip appears to be unaffected by hematocrit, ascorbic acid or acetaminophen. We recommend its use in neonates in hospital. Further studies are required to identify other interference effects.Keywords
This publication has 19 references indexed in Scilit:
- Two site evaluation of the performance of a new generation point-of-care glucose meter for use in a neonatal intensive care unitcclm, 2013
- Clinical performance of the new glucometer in the nursery and neonatal intensive care unitPediatrics International, 2011
- Measurement of glucose levels in the newbornEarly Human Development, 2010
- Analytical Performance of an Interference-Resistant Glucose MeterPoint of Care: The Journal of Near-Patient Testing & Technology, 2008
- Suitability Assessment of a New Bedside Interference Free Glucose System for Use in Critical Care When Compared to Current TechnologyPoint of Care: The Journal of Near-Patient Testing & Technology, 2008
- Patterns of Cerebral Injury and Neurodevelopmental Outcomes After Symptomatic Neonatal HypoglycemiaPediatrics, 2008
- Assessing glucose meter accuracyCurrent Medical Research and Opinion, 2006
- Hypoglycemia in Newborn Infants: Features Associated with Adverse OutcomesNeonatology, 2006
- Effects of Drugs on Glucose Measurements With Handheld Glucose Meters and a Portable Glucose AnalyzerAmerican Journal of Clinical Pathology, 2000
- Vitamin C at Concentrations Observed in Premature Babies Inhibits the Ferroxidase Activity of CaeruloplasminFree Radical Research, 1995