Protracted CRP Elevation after Atrial Fibrillation Ablation
- 28 August 2008
- journal article
- research article
- Published by Wiley in Pacing and Clinical Electrophysiology
- Vol. 31 (9), 1146-1151
- https://doi.org/10.1111/j.1540-8159.2008.01155.x
Abstract
Background: Atrial fibrillation (AF) has been linked to an inflammatory process detected through various biomarkers, including C‐Reactive Protein (CRP). Early recurrence of AF within the first 3 months after curative AF ablation is not felt to reflect success or failure of the procedure. We hypothesized that this early recurrence is due to an inflammatory response to the ablation itself. We therefore sought to evaluate levels of CRP after AF ablation. Methods: We prospectively enrolled subjects undergoing AF ablation. A control group of patients undergoing ablation for supraventricular tachycardia (SVT) was also enrolled. Each patient had CRP drawn on the day of the procedure (prior to ablation) and during their first follow‐up (median 49 days, interquartile range [IQR] 37–93) and second follow‐up (median 147 days, IQR 141–257) clinic visits. Patient interviews were performed and medical histories reviewed for evidence of recurrent AF prior to the first follow‐up. Results: CRP levels significantly increased from baseline to first follow‐up in the AF ablation group (P = 0.0017). CRP did not significantly change after SVT ablation (P = 0.92). Seventeen (45%) of the AF subjects exhibited recurrence of AF prior to first follow‐up. After adjusting for multiple potential confounders, AF ablation patients with recurrent AF prior to their first follow‐up had a statistically significant greater odds of having an increase in CRP (OR 21, 95% CI 1.1–417, P = 0.045). Conclusions: AF ablation generates an inflammatory response that persists for several weeks. This inflammation may explain early recurrence of AF after curative ablation.Keywords
This publication has 26 references indexed in Scilit:
- Acute Results of Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation Using a Single Mesh CatheterJournal of Cardiovascular Electrophysiology, 2009
- Markers of inflammation before and after curative ablation of atrial flutterHeart Rhythm, 2007
- Symptomatic and Asymptomatic Atrial Fibrillation in Patients Undergoing Radiofrequency Catheter AblationJournal of Cardiovascular Electrophysiology, 2006
- Correlation of Symptoms to ECG Diagnosis Following Atrial Fibrillation AblationJournal of Cardiovascular Electrophysiology, 2005
- Freedom From Atrial Tachyarrhythmias After Catheter Ablation of Atrial FibrillationCirculation, 2005
- Predictive Value of Early Atrial Tachyarrhythmias Recurrence After Circumferential Anatomical Pulmonary Vein AblationPacing and Clinical Electrophysiology, 2005
- Time courses and quantitative analysis of atrial fibrillation episode number and duration after circular plus linear left atrial lesions: Trigger elimination or substrate modification: Early or delayed cure?Journal of the American College of Cardiology, 2004
- Time courses and quantitative analysis of atrial fibrillation episode number and duration after circular plus linear left atrial lesionsTrigger elimination or substrate modification: Early or delayed cure?Journal of the American College of Cardiology, 2004
- Clinical significance of early recurrences of atrial fibrillation after pulmonary vein isolationJournal of the American College of Cardiology, 2002
- Histopathology of canine hearts subjected to catheter ablation using radiofrequency energy.Japanese Circulation Journal, 1994