Two-dimensional graphene analogues for biomedical applications
- 18 December 2014
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 44 (9), 2681-2701
- https://doi.org/10.1039/c4cs00300d
Abstract
The increasing demand of clinical biomedicine and fast development of nanobiotechnology has substantially promoted the generation of a variety of organic/inorganic nanosystems for biomedical applications. Biocompatible two-dimensional (2D) graphene analogues (e.g., nanosheets of transition metal dichalcogenides, transition metal oxides, g-C3N4, Bi2Se3, BN, etc.), which are referred to as 2D-GAs, have emerged as a new unique family of nanomaterials that show unprecedented advantages and superior performances in biomedicine due to their unique compositional, structural and physicochemical features. In this review, we summarize the state-of-the-art progress of this dynamically developed material family with a particular focus on biomedical applications. After the introduction, the second section of the article summarizes a range of synthetic methods for new types of 2D-GAs as well as their surface functionalization. The subsequent section provides a snapshot on the use of these biocompatible 2D-GAs for a broad spectrum of biomedical applications, including therapeutic (photothermal/photodynamic therapy, chemotherapy and synergistic therapy), diagnostic (fluorescent/magnetic resonance/computed tomography/photoacoustic imaging) and theranostic (concurrent diagnostic imaging and therapy) applications, especially on oncology. In addition, we briefly present the biosensing applications of these 2D-GAs for the detection of biomacromolecules and their in vitro/in vivo biosafety evaluations. The last section summarizes some critical unresolved issues, possible challenges/obstacles and also proposes future perspectives related to the rational design and construction of 2D-GAs for biomedical engineering, which are believed to promote their clinical translations for benefiting the personalized medicine and human health.Keywords
This publication has 188 references indexed in Scilit:
- Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumorsBiomaterials, 2013
- Mechanical Exfoliation and Characterization of Single‐ and Few‐Layer Nanosheets of WSe2, TaS2, and TaSe2Small, 2012
- Hybrid 2D Nanomaterials as Dual‐Mode Contrast Agents in Cellular ImagingAdvanced Materials, 2012
- Using Graphene Oxide High Near‐Infrared Absorbance for Photothermal Treatment of Alzheimer's DiseaseAdvanced Materials, 2012
- In vivo targeting and positron emission tomography imaging of tumor vasculature with 66Ga-labeled nano-grapheneBiomaterials, 2012
- Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic NanoparticlesAdvanced Materials, 2012
- Mesoporous Silica‐Coated Gold Nanorods as a Light‐Mediated Multifunctional Theranostic Platform for Cancer TreatmentAdvanced Materials, 2012
- Single‐Layer Semiconducting Nanosheets: High‐Yield Preparation and Device FabricationAngewandte Chemie-International Edition, 2011
- Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive T1 Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchymal Stem CellsJournal of the American Chemical Society, 2011
- Gold Nanocages: Synthesis, Properties, and ApplicationsAccounts of Chemical Research, 2008