The Immunomodulatory Potential of Wharton’s Jelly Mesenchymal Stem/Stromal Cells
Open Access
- 11 June 2019
- journal article
- review article
- Published by Hindawi Limited in Stem Cells International
- Vol. 2019, 1-7
- https://doi.org/10.1155/2019/3548917
Abstract
The benefits attributed to mesenchymal stem/stromal cells (MSC) in cell therapy applications are mainly attributed to the secretion of factors, which exhibit immunomodulatory and anti-inflammatory effects and stimulate angiogenesis. Despite the desirable features such as high proliferation levels, multipotency, and immune response regulation, there are important variables that must be considered. Although presenting similar morphological aspects, MSC collected from different tissues can form heterogeneous cellular populations and, therefore, manifest functional differences. Thus, the source of MSC should be a factor to be considered in the development of novel therapies. The following text presents an updated review of recent research outcomes related to Wharton’s jelly mesenchymal stem/stromal cells (WJ-MSC), harvested from umbilical cords and considered novel and potential candidates for the development of cell-based approaches. This text highlights information on how WJ-MSC affect immune responses in comparison with other sources of MSC.Funding Information
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
This publication has 81 references indexed in Scilit:
- Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophagesExperimental & Molecular Medicine, 2014
- Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell ApoptosisCell Stem Cell, 2012
- Immunomodulatory effect of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells on lymphocytesCellular Immunology, 2011
- Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral SclerosisArchives of Neurology, 2010
- Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs)Journal of Cellular and Molecular Medicine, 2010
- High Harvest Yield, High Expansion, and Phenotype Stability of CD146 Mesenchymal Stromal Cells from Whole Primitive Human Umbilical Cord TissueJournal of Biomedicine and Biotechnology, 2009
- Mesenchymal Stem Cell Transplantation Reverses Multiorgan Dysfunction in Systemic Lupus Erythematosus Mice and HumansThe International Journal of Cell Cloning, 2009
- The immunomodulatory activity of human umbilical cord blood‐derived mesenchymal stem cells in vitroImmunology, 2009
- Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 productionNature Medicine, 2008
- Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapiesMechanisms of Ageing and Development, 2008