Antagonism of EGFR and Notch limits resistance to EGFR inhibitors and radiation by decreasing tumor-initiating cell frequency
- 8 March 2017
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 9 (380)
- https://doi.org/10.1126/scitranslmed.aag0339
Abstract
An anti-EGFR/Notch antibody limits acquired resistance to EGFR inhibitors and radiation by reducing tumor-initiating cell frequency.Keywords
Funding Information
- National Natural Science Foundation of China (award288237)
- China Postdoctoral Science Foundation (award288238)
This publication has 52 references indexed in Scilit:
- Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 studyThe Lancet Oncology, 2011
- Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodiesProceedings of the National Academy of Sciences of the United States of America, 2011
- Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch SignalingCancer Research, 2010
- Targeting Nonhomologous End-Joining Through Epidermal Growth Factor Receptor Inhibition: Rationale and Strategies for RadiosensitizationSeminars in Radiation Oncology, 2010
- Highly tumorigenic lung cancer CD133 + cells display stem-like features and are spared by cisplatin treatmentProceedings of the National Academy of Sciences of the United States of America, 2009
- Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating featuresProceedings of the National Academy of Sciences of the United States of America, 2009
- Establishment and Characterization of a Model of Acquired Resistance to Epidermal Growth Factor Receptor Targeting Agents in Human Cancer CellsClinical Cancer Research, 2009
- Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer CellsCancer Research, 2008
- Analyzing real-time PCR data by the comparative CT methodNature Protocols, 2008
- Phenotypic characterization of human colorectal cancer stem cellsProceedings of the National Academy of Sciences of the United States of America, 2007