An MRI system for imaging neonates in the NICU: initial feasibility study
- 27 June 2012
- journal article
- Published by Springer Science and Business Media LLC in Pediatric Radiology
- Vol. 42 (11), 1347-1356
- https://doi.org/10.1007/s00247-012-2444-9
Abstract
Transporting premature infants from a neonatal intensive care unit (NICU) to a radiology department for MRI has medical risks and logistical challenges. To develop a small 1.5-T MRI system for neonatal imaging that can be easily installed in the NICU and to evaluate its performance using a sheep model of human prematurity. A 1.5-T MRI system designed for orthopedic use was adapted for neonatal imaging. The system was used for MRI examinations of the brain, chest and abdomen in 12 premature lambs during the first hours of life. Spin-echo, fast spin-echo and gradient-echo MR images were evaluated by two pediatric radiologists. All animals remained physiologically stable throughout the imaging sessions. Animals were imaged at two or three time points. Seven brain MRI examinations were performed in seven different animals, 23 chest examinations in 12 animals and 19 abdominal examinations in 11 animals. At each anatomical location, high-quality images demonstrating good spatial resolution, signal-to-noise ratio and tissue contrast were routinely obtained within 30 min using standard clinical protocols. Our preliminary experience demonstrates the feasibility and potential of the neonatal MRI system to provide state-of-the-art MRI capabilities within the NICU. Advantages include overall reduced cost and site demands, lower acoustic noise, improved ease of access and reduced medical risk to the neonate.Keywords
This publication has 47 references indexed in Scilit:
- Safety After Chloral Hydrate Sedation of Former Preterm and Term Infants for Magnetic Resonance Imaging: Are the Data Clear?Anesthesia & Analgesia, 2010
- Magnetic Resonance Imaging and Ultrasound Injury in Preterm Infants With SeizuresJournal of Child Neurology, 2009
- Procedural sedation of neonates with chloral hydrate: a sedation procedure does not end at the end of the acquisition of the imagesPediatric Anesthesia, 2008
- Sedation of children under 4 weeks of age for MRI examinationPediatric Anesthesia, 2008
- Abnormal Brain Development in Newborns with Congenital Heart DiseaseThe New England Journal of Medicine, 2007
- The Normal Neonatal Brain: MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term NeonatesAmerican Journal of Neuroradiology, 2007
- Magnetic resonance imaging protocols for paediatric neuroradiologyPediatric Radiology, 2007
- Advances in Magnetic Resonance Neuroimaging Techniques in the Evaluation of Neonatal EncephalopathyTopics in Magnetic Resonance Imaging, 2007
- Low field strength magnetic resonance imaging of the neonatal brainArchives of Disease in Childhood: Fetal & Neonatal, 2003
- Magnetic Resonance Imaging of Intestinal Necrosis in Preterm InfantsPEDIATRICS, 2000