New Clues in Celiac Disease Epidemiology, Pathogenesis, Clinical Manifestations, and Treatment
- 25 July 2011
- journal article
- review article
- Published by Taylor & Francis Ltd in International Reviews of Immunology
- Vol. 30 (4), 219-231
- https://doi.org/10.3109/08830185.2011.602443
Abstract
Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. It is one of the most common lifelong disorders on a worldwide basis. Celiac enteropathy is the final consequence of an abnormal immune reaction, showing features of both an innate and an adaptive response to gluten prolamins. The clinical spectrum is wide, including cases with either typical intestinal or atypical extraintestinal features, and silent forms. The only available treatment consists in dietary exclusion of grains containing gluten. New pharmacological treatment are currently under scrutiny.Keywords
This publication has 85 references indexed in Scilit:
- Coeliac disease in Libyan children: A screening study based on the rapid determination of anti-transglutaminase antibodiesDigestive and Liver Disease, 2011
- The prevalence of celiac disease in Europe: Results of a centralized, international mass screening projectAnnals of Medicine, 2010
- Analysis of HLA and Non-HLA Alleles Can Identify Individuals at High Risk for Celiac DiseaseGastroenterology, 2009
- Prevalence of Celiac Disease in Egyptian Children Disputes the East–West Agriculture‐dependent Spread of the DiseaseJournal of Pediatric Gastroenterology and Nutrition, 2008
- Genetic Background of Celiac Disease and Its Clinical ImplicationsThe American Journal of Gastroenterology, 2008
- High prevalence of celiac disease in Brazilian blood donor volunteers based on screening by IgA antitissue transglutaminase antibodyEuropean Journal of Gastroenterology & Hepatology, 2007
- Prevalence of Celiac Disease in At-Risk and Not-At-Risk Groups in the United StatesArchives of Internal Medicine, 2003
- Prevalence of celiac disease in argentina: screening of an adult population in the La Plata areaThe American Journal of Gastroenterology, 2001
- Prevalence of celiac disease among blood donors in BrazilThe American Journal of Gastroenterology, 2000
- The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school‐age subjectsActa Paediatrica, 1996