Enhancement of Osseointegration by Generating a Dynamic Implant Surface
- 1 April 2006
- journal article
- clinical trial
- Published by American Academy of Implant Dentistry in Journal of Oral Implantology
- Vol. 32 (2), 72-76
- https://doi.org/10.1563/736.1
Abstract
Preparations of autologous plasma rich in growth factors (PRGF) are used to promote healing and tissue regeneration. We seek to determine whether covering the titanium implant surface with this preparation could enhance osseointegration. The interaction of PRGF with the surface of titanium implants was examined by environmental scanning electron microscopy (ESEM). A total of 23 implants were placed in the tibiae and radii of 3 goats; 13 implants were inserted after covering the surface and filling the alveolus with PRGF, and 10 more implants were inserted following a conventional protocol and served as controls. Histomorphometric analysis of the bone-implant interface was performed after 8 weeks. Finally, 1391 implants were placed in 295 patients after bioactivating the surface with PRGF. Stability and implant survival were evaluated. The implant surface adsorbed the protein-rich material as shown by ESEM. In the animal study, osseointegration was enhanced when the surface was covered with PRGF as shown by histomorphometry (bone-implant contact: 51.28% ± 4.7% vs 21.89% ± 7.36%; P < .01). Finally, studies in patients showed that 99.6% of the implants treated with PRGF were well osseointegrated. Clinical use of this technique in oral implantology can improve the prognosis.Keywords
This publication has 10 references indexed in Scilit:
- Autologous platelets as a source of proteins for healing and tissue regenerationThrombosis and Haemostasis, 2004
- Plasma Rich in Growth Factors to Treat an Articular Cartilage Avulsion: A Case ReportMedicine & Science in Sports & Exercise, 2003
- THE ROLE OF GROWTH FACTORS IN THE REPAIR OF BONEThe Journal of Bone and Joint Surgery-American Volume, 2002
- Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applicationsJournal of Materials Science: Materials in Medicine, 2002
- Platelet concentration and its effect on bone formation in calvarial defects: An experimental study in rabbitsThe Journal of Prosthetic Dentistry, 2001
- Fibrin and Wound HealingAnnals of the New York Academy of Sciences, 2001
- Biologics in bone healingCurrent Orthopaedic Practice, 2000
- BMP stimulation of bone response adjacent to titanium implants in vivoClinical Oral Implants Research, 1999
- An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function.JCI Insight, 1995
- Provisional MatrixPublished by Springer Science and Business Media LLC ,1988