Study of 32 cases of Pick’s lobar atrophy offers evidence that one must distinguish some particular histopathological forms, characterized by the presence or absence of argyrophilic inclusions and/or neuronal swellings. In spite of the dissimilarities between these forms, considering the absence of sufficient knowledge about pathogenesis, it seems prudent at present to maintain the uniqueness of Pick’s entity. Otherwise, the clinical differences between these forms are not related to the nature of histological alterations but to the temporal or frontal predominance of the lesions.