Incorporating a Generic Model of Subcutaneous Insulin Absorption into the AIDA v4 Diabetes Simulator: 2. Preliminary Bench Testing
Open Access
- 1 September 2007
- journal article
- research article
- Published by SAGE Publications in Journal of Diabetes Science and Technology
- Vol. 1 (5), 780-793
- https://doi.org/10.1177/193229680700100525
Abstract
The AIDA interactive educational diabetes simulator has been available without charge for over a decade via the Internet (see www.2aida.org). Part 1 of this report [J Diabetes Sci Technol. 2007;1(3):423-35] described the model components to be integrated to enhance the utility of the software, with the aim being to provide enhanced functionality and educational simulations of regimens utilizing insulin analogues, as well as insulin doses greater than 40 units. This report provides some preliminary subcutaneous insulin absorption bench testing results for the updated modeling prototype. An analysis has been done of the spatial distribution of insulin in the region of the injection site for different classes of insulin preparations and times after the administration of a set insulin injection. Demonstrations of the proportion of residual insulin in depot versus time after a subcutaneous bolus have also been simulated for different insulin injection volumes and concentrations, as well as to show the proportions of hexameric, dimeric, and bound insulin over time after an injection. Some early bench testing results are highlighted following subcutaneous injections of a rapidly acting insulin analogue (such as lispro/Humalog or aspart/NovoLog), a short-acting (regular) insulin preparation (e.g., Actrapid), intermediate-acting insulins (both Semilente and neutral protamine Hagedorn types), and a very long-acting insulin analogue (such as glargine/Lantus). The transformation, dissociation/association, and absorption processes by which insulin moves from the subcutaneous injection site to the plasma are also illustrated. This report demonstrates how enhanced capabilities may be added to AIDA once a new model of subcutaneous insulin absorption is incorporated. The revised approach, once fully implemented, should permit the simulation of plasma insulin profiles for rapidly acting and very long-acting insulin analogues, as well as insulin injections greater than 40 units.Keywords
This publication has 8 references indexed in Scilit:
- Incorporating a Generic Model of Subcutaneous Insulin Absorption into the AIDA v4 Diabetes Simulator 3. Early Plasma Insulin DeterminationsJournal of Diabetes Science and Technology, 2009
- Incorporating a Generic Model of Subcutaneous Insulin Absorption into the AIDA v4 Diabetes SimulatorJournal of Diabetes Science and Technology, 2007
- Retrospective Pilot Feedback Survey of 200 Users of the AIDA Version 4 Educational Diabetes Program. 17—Quantitative Survey DataDiabetes Technology & Therapeutics, 2006
- Comprehensive Pharmacokinetic Model of Insulin Glargine and Other Insulin FormulationsIEEE Transactions on Biomedical Engineering, 2005
- Diabetes moves onto the InternetThe Lancet, 1996
- Pharmacokinetic Model for the Absorption of Subcutaneously Injected Soluble Insulin and Monomeric Insulin - Analogues - Pharmakokinetisches Modell für die Absorption von subkutan injiziertem löslichem Insulin und monomeren InsulinanalogaBiomedizinische Technik/Biomedical Engineering, 1993
- A physiological model of glucose-insulin interaction in type 1 diabetes mellitusJournal of Biomedical Engineering, 1992
- Modeling absorption kinetics of subcutaneous injected soluble insulinJournal of Pharmacokinetics and Biopharmaceutics, 1989