Identification of MFG-E8 as a novel therapeutic target for diseases
- 23 August 2013
- journal article
- review article
- Published by Informa Healthcare in Emerging Therapeutic Targets
- Vol. 17 (11), 1275-1285
- https://doi.org/10.1517/14728222.2013.829455
Abstract
Introduction: Milk fat globule-epidermal growth factor-factor 8 (MFG-E8), a peripheral membrane glycoprotein has been widely studied in recent years due to its omnipresent locations, express and multiple functions. Traditionally, MFG-E8 was identified as an outstanding factor for phagocytosis of apoptotic cells and a significant factor in immune systems. Recent studies with some new findings have shed an interesting light on the old peripheral membrane glycoprotein in various diseases. Areas covered: In inflammatory and the systemic lupus erythematosus-type autoimmune disease, age-related diseases and tumors, MFG-E8 plays a multifunctional role in attenuating inflammation and improving prognosis, healing wound and remodeling arterial and enhancing tumorigenicity and cancer metastasis. This review provides a comprehensive view on the latest advances in the field. The summarized knowledge will help to explore the potential therapeutic roles of MFG-E8 and to design MFG-E8-based strategies for the treatment of these diseases. Expert opinion: Though the exact roles of MFG-E8 have not been fully elucidated in diseases. MFG-E8 may serve as a promising therapeutic strategy.Keywords
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