MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS
- 1 April 2006
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 24 (1), 541-570
- https://doi.org/10.1146/annurev.immunol.23.021704.115830
Abstract
V(D)J recombination assembles antigen receptor variable region genes from component germline variable (V), diversity (D), and joining (J) gene segments. For B cells, such rearrangements lead to the production of immunoglobulin (Ig) proteins composed of heavy and light chains. V(D)J is tightly controlled at the Ig heavy chain locus (IgH) at several different levels, including cell-type specificity, intra- and interlocus ordering, and allelic exclusion. Such controls are mediated at the level of gene segment accessibility to V(D)J recombinase activity. Although much has been learned, many long-standing questions regarding the regulation of IgH locus rearrangements remain to be elucidated. In this review, we summarize advances that have been made in understanding how V(D)J recombination at the IgH locus is controlled and discuss important areas for future investigation.Keywords
This publication has 93 references indexed in Scilit:
- A Direct Interaction between the RAG2 C Terminus and the Core Histones Is Required for Efficient V(D)J RecombinationImmunity, 2005
- Epigenetic ontogeny of the Igk locus during B cell developmentNature Immunology, 2004
- Truncated immunoglobulin Dμ causes incomplete developmental progression of RAG-deficient pro-B cellsMolecular Immunology, 2002
- Frequencies of Multiple IgL Chain Gene Rearrangements in Single Normal or κL Chain–Deficient B Lineage CellsImmunity, 1999
- A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient MiceImmunity, 1996
- VDJ recombinationImmunology Today, 1992
- T-cell antigen receptor genes and T-cell recognitionNature, 1988
- Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphomaNature, 1986
- A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genesCell, 1985
- Chance, necessity and antibody gene dynamicsNature, 1983