Hypoglycemia in Type 1 and Type 2 Diabetes: Physiology, Pathophysiology,and Management
- 1 July 2006
- journal article
- Published by American Diabetes Association in Clinical Diabetes
- Vol. 24 (3), 115-121
- https://doi.org/10.2337/diaclin.24.3.115
Abstract
IN BRIEFThe threat and incidence of hypoglycemia is the major limiting factor in intensive glycemic control for both type 1 and type 2 diabetes. This article reviews the physiology of the normal counterregulatory responses to hypoglycemia and the deficient counterregulatory defenses that occur in patients with diabetes. Treatment paradigms for establishing good glycemic control while limiting hypoglycemia are also discussed.Keywords
This publication has 55 references indexed in Scilit:
- Hypoglycemia in diabetes: common, often unrecognized.Cleveland Clinic Journal of Medicine, 2004
- Hypoglycemia associated autonomic failureClinical Autonomic Research, 2002
- Avoidance of Hypoglycemia Restores Hypoglycemia Awareness by Increasing β-Adrenergic Sensitivity in Type 1 DiabetesAnnals of Internal Medicine, 2001
- Effect of the fast-acting insulin analog lispro on the risk of nocturnal hypoglycemia during intensified insulin therapy. U.K. Lispro Study Group.Diabetes Care, 1999
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998
- Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humansDiabetes, 1997
- Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humansDiabetes, 1991
- Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone releaseDiabetes, 1988
- Plasma Glucose Concentrations at the Onset of Hypoglycemic Symptoms in Patients with Poorly Controlled Diabetes and in NondiabeticsNew England Journal of Medicine, 1988
- Identification of Type I Diabetic Patients at Increased Risk for Hypoglycemia during Intensive TherapyNew England Journal of Medicine, 1983