Idiopathic nephrotic syndrome in South African children.
Open Access
- 8 January 2018
- journal article
- Published by African Journals Online (AJOL) in African Health Sciences
- Vol. 17 (4), 1130-1136
- https://doi.org/10.4314/ahs.v17i4.22
Abstract
Background: Different histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location. Objective: To provide an update on the steroid response and renal histo-pathological pattern in children treated for INS. Method: Medical records of children with INS treated at the Charlotte Maxeke Johannesburg Academic Hospital were reviewed. Results: Mean age was 5.3 years ± 2.8. The majority (68.1%) of the 163 children were of the black racial group. The highest rate of INS was seen in the 2-6 year age group (71.2%). The black racial group had the highest rate (42/111; 37.8%) of focal segmental glomerulosclerosis (FSGS), and the white race had the highest rate (9/14; 64.3%) of minimal change disease (MCD). Ninety four (57.7%) patients were steroid sensitive (SSNS) while 69 patients (42.3%) were steroid resistant (SRNS). Minimal change disease was the most common histo-pathological type seen in SSNS (60%), while FSGS was the most common observed in patients who had SRNS (65.2%). Conclusion: There appears to be a higher rate of FSGS in all the racial groups, and also a higher rate of MCD in the black race group, when compared to previous reports. Keywords: Idiopathic, nephrotic syndrome, children.Keywords
This publication has 23 references indexed in Scilit:
- Patterns of childhood nephrotic syndrome in Aljouf region, Saudi ArabiaSaudi Journal of Kidney Diseases and Transplantation, 2013
- Steroid-resistant idiopathic nephrotic syndrome in children: long-term follow-up and risk factors for end-stage renal diseaseBrazilian Journal of Nephrology, 2013
- Pathology of idiopathic nephrotic syndrome in children: are the adolescents different from young children?Nephrology Dialysis Transplantation, 2011
- Long-Term Outcome of Children with Steroid-Sensitive Idiopathic Nephrotic SyndromeClinical Journal of the American Society of Nephrology, 2009
- Primary nephrotic syndrome during childhood in TurkeyPediatrics International, 2004
- Is there really an increase in non-minimal change nephrotic syndrome in children?American Journal of Kidney Diseases, 2003
- The Management of Idiopathic Nephrotic Syndrome in ChildrenPediatric Drugs, 2003
- Changing patterns in the histopathology of idiopathic nephrotic syndrome in childrenKidney International, 1999
- Renal problems in black South African children.Pediatric Nephrology, 1997
- Treatment of the idiopathic nephrotic syndrome: regimens and outcomes in children and adults.1997