Interaction of L-Ascorbic Acid on the Disposition of Lead in Rats
- 31 March 1989
- journal article
- research article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 64 (4), 360-364
- https://doi.org/10.1111/j.1600-0773.1989.tb00665.x
Abstract
L-Ascorbic acid (As-Ac) has been investigated for its potential in the prophylaxis of lead poisoning. Using rats as the animal model, the pharmacokinetics of As-Ac was determined following a single intravenous dose (100 mg/kg) administered through a jugular vein. Plasma As-Ac levels were monitored using an enzyme assisted UV spectrophotometric method. The pharmacokinetic parameters of As-Ac obtained were used to establish a dosage regimen which cuold maintain its average plasma concentration of about 11 .mu.g/ml at steady in rats. The disposition of lead acetate (1 mg/kg) in rats was studied in the absence and presence of As-Ac at steady state. Lead concentrations were monitored in femur, kidney, liver and plasma over a 120 r period using flameless atomic absorption spectrophotomety. In presence of As-Ac, femur, kidney and liver demonstrated 56, 22 and 41% respective reductions in their exposure towards lead. In addition, the half-life of lead in femur and plasma was found to be reduced by 27 and 51% respectively.This publication has 23 references indexed in Scilit:
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