Dexamethasone in the post‐partum treatment of HELLP syndrome
- 1 December 1997
- journal article
- clinical trial
- Published by Wiley in International Journal of Gynecology & Obstetrics
- Vol. 59 (3), 217-221
- https://doi.org/10.1016/s0020-7292(97)00214-2
Abstract
Objective: To determine if the routine initiation of dexamethasone in patients with post-partum HELLP syndrome produces therapeutic benefits. Method: The puerperal courses of 17 mothers who initially received dexamethasone after delivery were compared to 17 other mothers with HELLP syndrome who received no corticosteroids during the puerperium course. Treated patients immediately received 10 mg of dexamethasone post-partum (intravenously) followed 12 h later by 10 mg and 10 mg at 24 h post-partum, to a total of 30 mg. Results: The steroid treated group had significant changes over time in platelet count. Relative to the control group the platelet count increased significantly by 30 h post-partum (PConclusion: Parturients with HELLP syndrome who received a short course of post-partum dexamethasone therapy had an accelerated recovery from their platelet count, but not from their liver enzymes and blood pressure.Keywords
This publication has 11 references indexed in Scilit:
- Better maternal outcomes are achieved using dexamethasone therapy for postpartum hellp syndromeAmerican Journal of Obstetrics and Gynecology, 1997
- Thrombocytopenia and mortality by eclampsiaInternational Journal of Gynecology & Obstetrics, 1997
- Postpartum corticosteroids: Accelerated recovery from the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP)American Journal of Obstetrics and Gynecology, 1994
- Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)American Journal of Obstetrics and Gynecology, 1993
- Pregnancy Complicated by Preeclampsia-Eclampsia With the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet CountObstetrics & Gynecology, 1990
- Platelets and the Beginnings of PreeclampsiaNew England Journal of Medicine, 1990
- The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): Much ado about nothing?American Journal of Obstetrics and Gynecology, 1990
- Syndrome of hemolysis, elevated liver enzymes, and low platelet count: A severe consequence of hypertension in pregnancyAmerican Journal of Obstetrics and Gynecology, 1982
- Pregnancy-induced hypertension complicated by acute liver disease and disseminated intravascular coagulationAmerican Journal of Obstetrics and Gynecology, 1975
- HEMATOLOGIC EVIDENCE OF DISSEMINATED INTRAVASCULAR COAGULATION IN ECLAMPSIAObstetrical & Gynecological Survey, 1972