The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
Open Access
- 14 October 2020
- journal article
- research article
- Published by American Society of Hematology in Blood Advances
- Vol. 4 (20), 4981-4989
- https://doi.org/10.1182/bloodadvances.2020002623
Abstract
Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95). A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation (P = .02) and CRRT (P = .004) and had a longer ICU stay (P = .03) compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients with blood group A or AB (n = 11) vs O or B (n = 14; P > .10 for all cytokines). Collectively, our data indicate that critically ill COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation, CRRT, and prolonged ICU admission compared with patients with blood group O or B. Further work is needed to understand the underlying mechanisms.This publication has 39 references indexed in Scilit:
- Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor bindingThe Lancet, 2020
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaThe Lancet, 2020
- ABO blood group is a determinant of von Willebrand factor protein levels in human pulmonary endothelial cellsJournal of Clinical Pathology, 2019
- The Simoa HD-1 Analyzer: A Novel Fully Automated Digital Immunoassay Analyzer with Single-Molecule Sensitivity and MultiplexingSLAS Technology, 2016
- ABO Blood Group as a Model for Platelet Glycan Modification in Arterial ThrombosisArteriosclerosis, Thrombosis, and Vascular Biology, 2015
- Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodiesGlycobiology, 2008
- Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implicationsThrombosis Journal, 2007
- ABO Blood Group and Susceptibility to Severe Acute Respiratory SyndromeJAMA, 2005
- The relationship between ABO histo‐blood group, factor VIII and von Willebrand factorTransfusion Medicine, 2001