Myrtenal inhibits acetylcholinesterase, a known Alzheimer target
- 19 August 2011
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 63 (10), 1368-1371
- https://doi.org/10.1111/j.2042-7158.2011.01344.x
Abstract
Objectives Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's disease. In this study selected components of essential oils, which carry a variety of important functional groups, were tested for their in-vitro anti-acetylcholinesterase activity. Methods In-vitro anti-acetylcholinesterase activity was measured by an adapted version of Ellman's colorimetric assay. Key findings 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mm). This is the first study showing the AChE inhibitory activity of myrtenal. Conclusions Our investigations provided evidence for the efficacy of monoterpenes as inhibitors of AChE.Keywords
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