Observations on the prophylaxis of experimental pulmonary anthrax in the monkey

Abstract

The evidence presented supports the hypothesis that the experimental form of anthrax induced by depositing a cloud of single spores on lung epithelium is initiated in the lymphatic regions and not in lung tissue. Proportionately few of the deposited spores reach the lymph glands. The majority remain inactive in so far as induction of disease is concerned. Slowly, however, they seem to go through the first stages of germination but do not multiply and therefore die. This is probably the major factor operative in their disappearance from the lung. Effective prophylactic measures are suggested for dealing with an unimmunized host exposed to anthrax infection by the pulmonary route.