Translation of Amnion Stem Cells to the Clinic
- 1 December 2013
- journal article
- research article
- Published by Mary Ann Liebert Inc in Stem Cells and Development
- Vol. 22 (S1), 96-102
- https://doi.org/10.1089/scd.2013.0391
Abstract
Cellular therapy for liver disease has been available in the clinic for more than 20 years, yet remarkably few patients receive this experimental therapy. Reasons for the small number of transplants performed are partially related to access to useful liver tissue and the difficulty with the isolation of viable cells. Stem cell sources of hepatocytes could theoretically relieve these obstacles to therapy if large numbers of functional hepatocytes could be generated and transplanted without risk of tumorigenicity. To date, there are no reports of stem cell sources with all of these characteristics, despite claims otherwise. Here we report the results of preclinical studies with appropriate animals models of metabolic liver disease and acute liver failure, and their correction by the transplantation of human amnion epithelial stem cells. The encouraging results of the preclinical studies have motivated the movement of isolation and banking of these cells to good manufacturing practice conditions so that the cells can be used in the clinic for transplantation of patients with liver disease.Keywords
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