Arginine-Glycine-Aspartic Acid Motif Is Critical for Human Parechovirus 1 Entry
Open Access
- 15 October 2001
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (20), 10000-10004
- https://doi.org/10.1128/jvi.75.20.10000-10004.2001
Abstract
The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal. These studies indicate that the RGD motif plays a critical role in infectivity, presumably by interacting with integrins, and that downstream amino acids can have an influence on function.Keywords
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