DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
- 30 October 2015
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 350 (6260), 568-571
- https://doi.org/10.1126/science.aab3291
Abstract
Viral oncogenes remove the host's STING: Cancer-causing viruses, such as the human papilloma virus (HPV) that causes cervical cancer, account for 12% of human cancers. One way they can cause cancer is by targeting tumor suppressor proteins in the host. Now Lau et al. report that DNA tumor viruses can also thwart the host's immune system. Oncogenes from HPV and human adenovirus bound to the protein STING, a key component of the cGAS-STING pathway that senses and defends against intracellular DNA. In this way, the viruses subvert the host's antiviral immunity and set up shop, which, for an unlucky few, eventually causes cancer. Science , this issue p. 568Keywords
Funding Information
- Burroughs Wellcome Fund
- Cancer Research Institute
- Rita Allen Foundation
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