Bioinorganic Magnetic Core−Shell Nanocomposites Carrying Antiarthritic Agents: Intercalation of Ibuprofen and Glucuronic Acid into Mg−Al−Layered Double Hydroxides Supported on Magnesium Ferrite
- 19 August 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 48 (18), 8871-8877
- https://doi.org/10.1021/ic901097a
Abstract
This paper describes the synthesis and characterization of a composite constituted by an antiarthritic agent (AA) intercalated into a layered double hydroxide (LDH) supported on magnesium ferrite. Core−shell nanocomposites were prepared by depositing Mg−Al−NO3−LDH on a MgFe2O4 core prepared by calcination of a nonstoichiometric Mg−Fe−CO3−LDH. Intercalation of ibuprofen and glucuronate anions was performed by ion-exchange with nitrate ions. The structural characteristics of the obtained products were investigated by powder X-ray diffraction, element chemical analysis, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Morphologies of the nanocomposite particles were examined by scanning electron microscopy and transmission electron microscopy. The products were shown to intercalate substantial amounts of AA with enhanced thermal stabilities. Room-temperature magnetic measurements by vibrating sample magnetometry revealed that the products show soft ferromagnetic properties suitable for potential utilization in magnetic arthritis therapy.Keywords
This publication has 35 references indexed in Scilit:
- A novel core-shell structured magnetic organic-inorganic nanohybrid involving drug-intercalated layered double hydroxides coated on a magnesium ferrite core for magnetically controlled drug releaseJournal of Materials Chemistry, 2009
- Release studies of different NSAIDs encapsulated in Mg,Al,Fe-hydrotalcitesApplied Clay Science, 2009
- Solubility and release of fenamates intercalated in layered double hydroxidesClay Minerals, 2008
- Stoichiometric Synthesis of Pure MFe2O4 (M = Mg, Co, and Ni) Spinel Ferrites from Tailored Layered Double Hydroxide (Hydrotalcite-Like) PrecursorsChemistry of Materials, 2004
- Thermal decomposition of some analgesic agentsJournal of Thermal Analysis and Calorimetry, 1996
- Synthesis and Characterization of Tetraborate Pillared HydrotalciteChemistry of Materials, 1996
- PREPARATION AND CHARACTERIZATION OF MAGNESIUM CHROMITE AND MAGNESIUM FERRITE AEROGELSChemical Engineering Communications, 1993
- Hydrotalcite-type anionic clays: Preparation, properties and applications.Catalysis Today, 1991
- The crystal structures of the dihydrated potassium and rubidium salts of β-D-glucuronic acidActa Crystallographica, 1963
- THERMAL DECARBOXYLATION OF URONIC ACIDSCanadian Journal of Chemistry, 1952