Nd:YAG laser‐induced hyperthermia in a mouse tumor model
- 1 January 1988
- journal article
- research article
- Published by Wiley in Lasers in Surgery and Medicine
- Vol. 8 (5), 510-514
- https://doi.org/10.1002/lsm.1900080510
Abstract
Hyperthermic tumor response induced by 1,064-nm radiation from an Nd:YAG laser was investigated in DBA/2J female mice bearing the SMT-F mammary carcinoma. The measured temperature-depth profiles indicate that hyperthermic temperatures can be achieved in tumors ranging from 3 to 8 mm thick at power inputs on the order of 1 W. For small tumors, a 5-week complete response rate exceeding 50% required 45 minutes at 45.0°C. Control of large tumors (6–8 mm thick) was not achieved. The observed tumor response rates are consistent with semiempirical time-temperature relations based on other heating modalities.Keywords
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