Reversible alteration in the neuromuscular junctions of Drosophila melanogaster bearing a temperature-sensitive mutation, shibire.
Open Access
- 1 June 1979
- journal article
- research article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 81 (3), 520-527
- https://doi.org/10.1083/jcb.81.3.520
Abstract
In this study we report a relationship between the ultrastruct of the neuromuscular junctions of tibial muscles and the temperature-induced paralysis in shibire flies. There is a decrease in the number of synaptic vesicles of neuromuscular junctions in flies which are held at or above 29 degrees. Shortly after return to 22 degrees C, the synaptic vesicles are again present in large numbers. Prior treatment with tetrodotoxin or barbiturate protects the junctions from the temperature change in morphology.This publication has 3 references indexed in Scilit:
- Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America, 1976
- The Effects of Increased Temperature on Electroretinograms of Temperature-Sensitive Paralysis Mutants of Drosophila melanogasterProceedings of the National Academy of Sciences of the United States of America, 1974
- Developmental properties of shibirets1: A pleiotropic mutation affecting larval and adult locomotion and developmentDevelopmental Biology, 1973