Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis
Open Access
- 1 January 2009
- journal article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 33 (1), 99-106
- https://doi.org/10.1183/09031936.00091607
Abstract
The aim of the present study was to investigate the prevalence of muscle weakness and the importance of physical inactivity in cystic fibrosis (CF), and its relationship to exercise tolerance and muscle strength. Exercise tolerance, skeletal and respiratory muscle strength were studied in a group of 64 adults with CF (age 26±8 yrs, FEV1 % predicted 65±19) and in 20 age-matched controls. Physical activity (PA) was assessed in 20 patients and all controls. Quadriceps muscle weakness was present in 56% of the patients. Peak oxygen uptake and 6-min walking distance were below normal in 89 and 75% of patients, respectively. Respiratory muscle strength was normal. The differences remained after correcting for PA. Quadriceps force was correlated to the 6-min walking distance but not to peak oxygen uptake. “Mild” PA (>3 metabolic equivalents (METS)) and the number of steps overlapped with controls, but CF patients had less moderate PA (>4.8 METS). Moderate PA was related to peak oxygen uptake and quadriceps force. Skeletal muscle weakness and exercise intolerance are prevalent in cystic fibrosis. Physical inactivity is a factor significantly contributing to exercise tolerance and skeletal muscle force in adults with cystic fibrosis, but these impairments are in excess to that expected from physical inactivity only.This publication has 21 references indexed in Scilit:
- Hypomagnesaemia in cystic fibrosis patients referred for lung transplant assessmentJournal of Cystic Fibrosis, 2007
- Physical activity is independently related to aerobic capacity in cystic fibrosisEuropean Respiratory Journal, 2006
- Analysis of Bone Mineral Density and Turnover in Patients with Cystic Fibrosis: Associations between the IGF System and Inflammatory CytokinesHormone Research in Paediatrics, 2006
- Respiratory factors do not limit maximal symptom-limited exercise in patients with mild cystic fibrosis lung diseaseRespiratory Physiology & Neurobiology, 2006
- The systemic inflammatory response to exercise in adults with cystic fibrosisJournal of Cystic Fibrosis, 2006
- Inhaled beta-agonists improve lung function but not maximal exercise capacity in cystic fibrosisJournal of Cystic Fibrosis, 2005
- Muscular Strength and Function in Patients With Cystic FibrosisSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2005
- Gender differences in habitual activity in children with cystic fibrosisArchives of Disease in Childhood, 2004
- How Many Steps/Day Are Enough?Sports Medicine, 2004
- ACSM Position Stand: The Recommended Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in Healthy AdultsMedicine & Science in Sports & Exercise, 1998