Antitumor Activity ofCitrus maxima(Burm.) Merr. Leaves in Ehrlich's Ascites Carcinoma Cell-Treated Mice
Open Access
- 19 April 2011
- journal article
- Published by Hindawi Limited in ISRN Pharmacology
- Vol. 2011, 1-4
- https://doi.org/10.5402/2011/138737
Abstract
Context. The plant Citrus maxima Merr. (Rutaceae), commonly known as shaddock or pomelo is indigenous to tropical parts of Asia. The objective of present study is to evaluate the methanol extract of Citrus maxima leaves for its antitumor activity against Ehrlich's Ascites Carcinoma cell in Swiss albino mice. Experimental design. The antitumor activity of methanol extract of Citrus maxima leaves (MECM) was evaluated against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. 2 × 106 cells were inoculated in different groups of animals. MECM (200 and 400 mg/kg BW i.p.) was administered for nine consecutive days. On day 10th half the animals of different groups were sacrificed for determination of tumor and haematological parameters and the rest half were kept with sufficient food and water ad libitum for determination of increase in life span. Result and Discussions. Oral administration of the extract at the doses of 200 and 400 mg/kg significantly decreased tumor parameters such as tumor volume, viable tumor cell count and increased body weight, hematological parameters and life span in respect of the EAC control mice. Conclusion. Experimental design exhibits significant antitumor activity of the extract (MECM) in a dose dependant manner.This publication has 12 references indexed in Scilit:
- Antitumor activity ofSansevieria roxburghianarhizome against Ehrlich ascites carcinoma in micePharmaceutical Biology, 2010
- Chemical profile, antifungal, antiaflatoxigenic and antioxidant activity of Citrus maxima Burm. and Citrus sinensis (L.) Osbeck essential oils and their cyclic monoterpene, dl-limoneneFood and Chemical Toxicology, 2010
- Evaluation of anticancer activity of Cleome gynandra on Ehrlich's Ascites Carcinoma treated miceJournal of Ethnopharmacology, 2010
- Antioxidant potentials of buntan pumelo (Citrus grandis Osbeck) and its ethanolic and acetified fermentation productsFood Chemistry, 2010
- Induction of apoptosis in U937 human leukaemia cells by the hexane fraction of an extract of immature Citrus grandis Osbeck fruitsFood Chemistry, 2009
- Anticancer activity of an essential oil from Cymbopogon flexuosusChemico-Biological Interactions, 2009
- Juice components and antioxidant capacity of citrus varieties cultivated in ChinaFood Chemistry, 2008
- Pharmacological properties of citrus and their ancient and medieval uses in the Mediterranean regionJournal of Ethnopharmacology, 2005
- Buntanbismine, a bisacridone alkaloid from Citrus grandis f. buntanPhytochemistry, 1996
- The Role of Viruses in the Production of CancerAdvances in Cancer Research, 1954