Minocycline‐related cutaneous hyperpigmentation as demonstrated by light microscopy, electron microscopy and X‐ray energy spectroscopy*
- 1 June 1987
- journal article
- research article
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 14 (3), 176-180
- https://doi.org/10.1111/j.1600-0560.1987.tb00493.x
Abstract
A 70-year-old patient with a chronic cutaneous ulcer treated by minocycline hydrochloride developed hyperpigmentation of the forearms. Biopsy material was studied by light microscopy, electron microscopy and X-ray energy spectroscopy. Granular goldbrown pigment was found in dermal histiocytes and eccrine myoepithelial cells, which gave positive reaction with Prussian blue and Fontana-Masson stains. Electron microscopy revealed intracytoplasmic granules of dark, homogeneous material and small fine particles. X-ray energy spectroscopy showed iron and other elements in smaller amounts. The different types of minocycline-related hyperpigmentation and the possible pathomechanism are discussed with special regard to the importance of the diagnostic methods.This publication has 21 references indexed in Scilit:
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