Determination of cisplatin and some possible metabolites by ion-pairing chromatography with inductively coupled plasma mass spectrometric detection
- 19 May 1993
- journal article
- Published by Elsevier BV in Journal of Chromatography B: Biomedical Sciences and Applications
- Vol. 615 (1), 83-89
- https://doi.org/10.1016/0378-4347(93)80293-d
Abstract
A sensitive method is described for measuring cisplatin and some possible metabolites. The method combines reversed-phase ion-pairing liquid chromatography (LC) with inductively coupled plasma mass spectrometry (ICP-MS) for platinum-specific detection. Separation conditions for cisplatin hydrolysis products and the reaction products of cisplatin with methionine, cysteine, and glutathione have been investigated with sodium dodecylsulfate or heptanesulfonate as the ion-pairing agent. The detection limit for cisplatin was found to be 0.1 ng, corresponding to a concentration detection limit of 1 ng/ml when using an injection volume of 100 microliters. This study has demonstrated the usefulness of LC-ICP-MS for cisplatin metabolism studies.Keywords
This publication has 22 references indexed in Scilit:
- Element-Specific Detection of Metallodrugs and Their MetabolitesPublished by American Chemical Society (ACS) ,1992
- Determination of gold-based antiarthritis drugs and their metabolites in urine by reversed-phase ion-pair chromatography with ICP-MS detectionJournal of Pharmaceutical and Biomedical Analysis, 1992
- Studies of platinum(II) methionine complexes: metabolites of cisplatinInorganic Chemistry, 1992
- Inductively coupled plasma mass spectrometry for the determination of platinum in animal tissues and a comparison with atomic absorption spectrometryJournal of Analytical Atomic Spectrometry, 1990
- The late effects of cis-platinum on renal functionEuropean Journal of Cancer and Clinical Oncology, 1989
- Protective effect of reduced glutathione against cisplatin-induced renal and systemic toxicity and its influence on the therapeutic activity of the antitumor drugChemico-Biological Interactions, 1989
- Optimization of secondary chemical equilibria in liquid chromatography: variables influencing the self-selectivity, retention, and efficiency in acid-base systemsAnalytical Chemistry, 1987
- High-performance liquid chromatographic determination of platinum (II) in plasma ultrafiltrate and urine: comparison with a flameless atomic absorption spectrometric methodClinica Chimica Acta; International Journal of Clinical Chemistry, 1984
- Efficiency enhancement in micellar liquid chromatographyAnalytical Chemistry, 1983
- Alterations in the toxicity of cis-Dichlorodiammineplatinum-II and in tissue localization of platinum as a function of NaCl concentration in the vehicle of administrationToxicology and Applied Pharmacology, 1981