Diastereoselective Synthesis of All Stereoisomers of β-Methoxytyrosine, a Component of Papuamides
- 26 November 2002
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (26), 9210-9215
- https://doi.org/10.1021/jo0258352
Abstract
β-Methoxytyrosine (β-OMeTyr) is a stereoundefined component of papuamides A and B, novel cyclodepsipeptides, with anti-HIV and cytotoxic activities. For structural determination and total synthesis of papuamides, all stereoisomers of β-OMeTyr were stereoselectively prepared from (S)- and (R)-serine, respectively.Keywords
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