First Examples of Improved Catalytic Asymmetric C−C Bond Formation Using the Monodentate Ligand Combination Approach
- 22 July 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (17), 3111-3113
- https://doi.org/10.1021/ol035106o
Abstract
Using a combination of chiral monodentate phosphoramidite ligands in the rhodium-catalyzed conjugate addition of boronic acids to three different substrates, we have shown for the first time that the ligand combination approach is applicable for C−C bond formation. Chiral catalysts based on hetero-combinations of ligands are found to be more effective than the homo-combinations. 31P NMR experiments show that the hetero-combinations are formed in excess over the homo-combinations.Keywords
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