Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
Top Cited Papers
- 12 August 2004
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 351 (7), 657-667
- https://doi.org/10.1056/nejmoa040258
Abstract
The progression of chronic myelogenous leukemia (CML) to blast crisis is supported by self-renewing leukemic stem cells. In normal mouse hematopoietic stem cells, the process of self-renewal involves the β-catenin–signaling pathway. We investigated whether leukemic stem cells in CML also use the β-catenin pathway for self-renewal.Keywords
This publication has 55 references indexed in Scilit:
- Activation of β-catenin–TCF-mediated transcription by non-receptor tyrosine kinase v-SrcBiochemical and Biophysical Research Communications, 2004
- Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid LeukemiaNew England Journal of Medicine, 2003
- MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasionOncogene, 2003
- Hematopoiesis and stem cells: plasticity versus developmental heterogeneityNature Immunology, 2002
- Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or AmplificationScience, 2001
- Chronic Myeloid LeukemiaNew England Journal of Medicine, 1999
- Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon CarcinomaScience, 1997
- Differential Complementation of Bcr-Abl Point Mutants with c-MycScience, 1994
- Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene ProductsScience, 1990
- Induction of Chronic Myelogenous Leukemia in Mice by the P210
bcr/abl
Gene of the Philadelphia ChromosomeScience, 1990