The MoCA
Top Cited Papers
- 9 November 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 75 (19), 1717-1725
- https://doi.org/10.1212/wnl.0b013e3181fc29c9
Abstract
Objective: To establish the diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) when screening externally validated cognition in Parkinson disease (PD), by comparison with a PD-focused test (Scales for Outcomes in Parkinson disease–Cognition [SCOPA-COG]) and the standardized Mini-Mental State Examination (S-MMSE) as benchmarks. Methods: A convenience sample of 114 patients with idiopathic PD and 47 healthy controls was examined in a movement disorders center. The 21 patients with dementia (PD-D) were diagnosed using Movement Disorders Society criteria, externally validated by detailed independent functional and neuropsychological tests. The 21 patients with mild cognitive impairment (PD-MCI) scored 1.5 SD or more below normative data in at least 2 measures in 1 of 4 cognitive domains. Other patients had normal cognition (PD-N). Results: Primary outcomes using receiver operating characteristic (ROC) curve analyses showed that all 3 mental status tests produced excellent discrimination of PD-D from patients without dementia (area under the curve [AUC], 87%–91%) and PD-MCI from PD-N patients (AUC, 78%–90%), but the MoCA was generally better suited across both assessments. The optimal MoCA screening cutoffs were <21/30 for PD-D (sensitivity 81%; specificity 95%; negative predictive value [NPV] 92%) and <26/30 for PD-MCI (sensitivity 90%; specificity 75%; NPV 95%). Further support that the MoCA is at least equivalent to the SCOPA-COG, and superior to the S-MMSE, came from the simultaneous classification of the 3 PD patient groups (volumes under a 3-dimensional ROC surface, chance = 17%: MoCA 79%, confidence interval [CI] 70%–89%; SCOPA-COG 74%, CI 62%–86%; MMSE-Sevens item 56%, CI 44%–68%; MMSE-World item 62%, CI 50%–73%). Conclusions: The MoCA is a suitably accurate, brief test when screening all levels of cognition in PD.Keywords
This publication has 39 references indexed in Scilit:
- Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson diseaseNeurology, 2009
- Cognitive Characteristics Associated with Mild Cognitive Impairment in Parkinson’s DiseaseDementia and Geriatric Cognitive Disorders, 2009
- Quantification of Five Neuropsychological Approaches to Defining Mild Cognitive ImpairmentAmerican Journal of Geriatric Psychiatry, 2009
- Mild cognitive impairment is common in Parkinson's disease patients with normal Mini-Mental State Examination (MMSE) scoresParkinsonism & Related Disorders, 2009
- Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's diseaseAnnals of Neurology, 2009
- Functional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementiaJournal of Neurology, Neurosurgery & Psychiatry, 2009
- Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination ScoreJournal of the American Geriatrics Society, 2009
- ROC Graphs for Assessing the Ability of a Diagnostic Marker to Detect Three Disease Classes with an Umbrella OrderingBiometrics, 2007
- The Alzheimer's Disease Activities of Daily Living International Scale (ADL-IS)International Psychogeriatrics, 2001
- The Neuropsychiatric InventoryNeurology, 1994