Insulin-Dependent Diabetes Mellitus and Autoimmunity: Islet-Cell Autoantibodies, Insulin Autoantibodies, and Beta-Cell Failure
- 3 October 1985
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 313 (14), 893-894
- https://doi.org/10.1056/nejm198510033131417
Abstract
To the Editor: In February 1983 the Journal published our report of islet-cell autoantibodies and beta-cell function in monozygotic triplets (19.11 and 16.11[b]) and a monozygotic twin (18.12) initially discordant for insulin-dependent diabetes mellitus (IDDM).1 This report showed (1) the detection in genetically susceptible persons of circulating islet-cell antibodies (reacting with undefined islet-cell antigens on pancreatic sections) before the apparently "acute" clinical onset of IDDM, (2) a slowly progressive reduction in beta-cell function (the early-phase insulin response to intravenous glucose) during the "prediabetic phase" of this disease, and (3) relatively normal indexes of glucose homeostasis (such as fasting blood . . .This publication has 4 references indexed in Scilit:
- Insulin antibodies in patients receiving penicillamineAmerican Journal Of Medicine, 1985
- Increased prevalence of coeliac disease in diabetes.Archives of Disease in Childhood, 1984
- Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin TreatmentScience, 1983
- Islet-Cell Antibodies and Beta-Cell Function in Monozygotic Triplets and Twins Initially Discordant for Type I Diabetes MellitusNew England Journal of Medicine, 1983