A new route to (–)-cherylline via a regiocontrolled polonovski-type reaction as the key step

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Abstract
A facile and efficient synthesis of (–)-cherylline (1) was accomplished in 46% overall yield starting from the readily accessible (12S)-(–)-3,9-dibenzyloxy-2-methoxy-tetrahydro-6,12-methanodibenz[c.f]azocine (4)viaa regiocontrolled Polonovski-type reaction as the key step.