Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation
Open Access
- 15 February 2012
- journal article
- review article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 95 (2), 165-172
- https://doi.org/10.1093/cvr/cvs094
Abstract
Smooth muscle cells (SMCs) are the main cell type in intimal thickenings and some stages of human atherosclerosis. Like monocyte-derived macrophages, SMCs accumulate excess lipids and contribute to the total intimal foam cell population. In contrast, apolipoprotein (Apo)E-deficient and LDL receptor-deficient mice develop atherosclerotic lesions that are macrophage- as opposed to SMC-rich. The lesser contribution of SMCs to lesion development in these mouse models has distracted attention away from the importance of SMC cholesterol homeostasis in the artery wall. Intimal SMCs accumulate excess amounts of cholesteryl esters when compared with medial layer SMCs, possibly explained by reduced ATP-binding cassette transporter A1 expression and ApoA-I binding to intimal-type SMCs. The aim of this review is to compare the relative contribution of monocyte-derived macrophages and SMCs to human vs. mouse atherosclerosis, and describe what is known about lipid uptake and removal mechanisms contributing to arterial macrophage and SMC foam cell formation. An increased understanding of the contribution of these cell types to lesion development will help to delineate their relative importance in atherogenesis and as potential therapeutic targets.Keywords
This publication has 93 references indexed in Scilit:
- Lysosomal Acid Lipase Deficiency Impairs Regulation of ABCA1 Gene and Formation of High Density Lipoproteins in Cholesteryl Ester Storage DiseasePublished by Elsevier BV ,2011
- Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid LipaseCell Metabolism, 2011
- Scavenger receptor SR-BI in macrophage lipid metabolismAtherosclerosis, 2011
- The complexity of HDLBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
- A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathwaysBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
- Acyl-coenzyme A:cholesterol acyltransferasesAmerican Journal of Physiology-Endocrinology and Metabolism, 2009
- Immune and Inflammatory Mechanisms of AtherosclerosisAnnual Review of Immunology, 2009
- Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/IICardiovascular Research, 2007
- Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosisThe Journal of Experimental Medicine, 2006
- Oxidized LDL Induces Apoptosis in Cultured Smooth Muscle Cells: A Possible Role for 7-KetocholesterolBiochemical and Biophysical Research Communications, 1996